SEMIoTICS main scope aims to develop a pattern-driven framework, built upon existing IoT platforms, to enable and guarantee secure and dependable actuation and semi-autonomic behaviour in IoT/IIoT applications. The SEMIoTICS framework will support cross-layer intelligent dynamic adaptation, including heterogeneous smart objects, networks and clouds. To address the complexity and scalability needs within horizontal and vertical domains, SEMIoTICS will develop and integrate smart programmable networking and semantic interoperability mechanisms. The above will be validated by industry, using three diverse usage scenarios in the areas of renewable energy, healthcare, and smart sensing and will be offered through an open API.